Table 3.

Clinical efficacy of curcumin supplementation in ulcerative colitis

Study	Study Design	Trial Size	Study Duration (weeks)	Medications	Daily Curcuminoid Intake (mg/day)	Clinical Outcomes in Curcumin Group	Laboratory Outcomes in Curcumin Group
2017 Kedia [36]	DB, PC, RCT	62	8	Mesalamine	450	⇄ Clinical remission, clinical response, mucosal healing, treatment failure	N/A
2015 Lang A [37]	DB, PC, RCT	50	4	Mesalamine	3000	↑ Clinical and endoscopic remission. ↓ SCCAI	N/A
2006 Hanai [38]	DB, PC, RCT, multicenter	89	24	Sulfasalazine or Mesalamine	2000	↓ Clinical activity index, endoscopic index, Relapse occurrence	N/A

↑↓ Indicates an increase or decrease in the value of the respective variable, ⇄ Indicates that no change occurred in that respective variable. Abbreviations: ACR: American College of Rheumatology (criterion). CRP: C-reactive protein levels. DAS: Disease activity score (Part of DAS28). DB: Double-blind. ESR: Erythrocyte sedimentation rate. PC: Placebo controlled. RCT: Randomized controlled trial. SB: Single blind. SCCAI: Simple clinical colitis activity index. SZ: Sulfasalazine. VAS: Visual analogue scale.