Table 4.
Clinical efficacy of curcumin supplementation in rheumatoid arthritis and lupus nephritis
| Study | Study Design | Trial Size | Study Duration (weeks) | Daily Curcuminoid Intake (mg/day) | Clinical Outcomes in Curcumin Group | Laboratory Outcomes in Curcumin Group |
|---|---|---|---|---|---|---|
| 2012 Chandran [39] | SB, RCT | 45 | 8 | 1000 | ↓ ACR, DAS, VAS | ⇄ Blood parameters, ESR. ↓ CRP |
| 1980 Deodhar [40] | DB. RCT | 18 | 2 | 1300 | ⇄ DAS | N/A |
| 2012 Khajehdehi [41] | DB, PC, RCT | 24 | 12 | 66.3 | N/A | ↓ Proteinuria, systolic blood pressure, hematuria |
↑↓ Indicates an increase or decrease in the value of the respective variable, ⇄ Indicates that no change occurred in that respective variable. Abbreviations: ACR: American College of Rheumatology (criterion). CRP: C-reactive protein levels. DAS: Disease activity score (Part of DAS28). DB: Double-blind. ESR: Erythrocyte sedimentation rate. PC: Placebo controlled. RCT: Randomized controlled trial. SB: Single blind. SCCAI: Simple clinical colitis activity index. SZ: Sulfasalazine. VAS: visual analogue scale.