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Structure of the 26S proteasome (based on PDB: 4CR2). The 26S proteasome consists of a 20S CP (orange) and a 19S RP (gray or indicated colors). The CP is responsible for proteolysis. The RP contains the ATPase subunits Rpt1–6 (purple), the deubiquitinase Rpn11 (cyan), and the ubiquitin receptors Rpn1, Rpn10, and Rpn13 (green). Substrates enter the proteasome through a channel at the center of a ring formed by the ATPase subunits.
