Figure 2.

The proteasomal degradation signal has two parts. (a) Schematic representation of a proteasome substrate. A substrate protein (green) has to contain a proteasome‐binding tag (typically poly‐ubiquitin chains, yellow) and an unstructured region (red) for efficient degradation. (b) Substrate engagement by the proteasome. The proteasome recognizes a substrate via the ubiquitin tag and engages it at the disordered region for unfolding and translocation from the 19S RP to 20S CP.