ERK |
extracellular signal-regulated kinase |
JNK |
c-Jun amino-terminal kinase |
MAPK |
mitogen-activated protein kinases |
TKR |
tyrosine kinase receptors |
RAS |
rat sarcoma 2 viral oncogene homolog |
RAF |
rapidly accelerated fibrosarcoma |
MEK |
MAPK/ERK kinase |
CD120 |
cluster of differentiation 120 |
Syk |
spleen tyrosine kinase |
SRC-1 |
steroid receptor coactivator-1 |
Pax6 |
paired box protein 6 |
NFAT |
nuclear factor of activated T-cells |
Elk-1 |
ETS domain-containing protein-1 |
MEF2 |
myocyte enhancer factor-2 |
AP1 |
activator protein-1 (c-jun and c-fos) |
c-myc |
avian myelocytomatosis virus oncogene cellular homolog |
STAT |
signal transducer and activator of transcription-3 |
RSK |
ribosomal S6 kinase |
MSK |
mitogen-and stress-activated kinase |
DNMT3B |
DNA (cytosine -5-)-methyltransferase 3β |
CDK |
cyclin-dependent kinases |
eIF2B |
eukaryotic translation initiation factor 2β |
GSK3β |
glycogen synthase kinase 3-β |
CREBP |
cAMP response element-binding protein |
SRF |
serum response factor |
NF-kB |
nuclear factor-kB |
HMG14 |
high mobility group-14 |
TCGA |
Tissue Cancer Genome Atlas |
UTR |
untranslated region |
EGFR |
epidermal growth factor receptor |
Her2 |
receptor tyrosine-protein kinase erbB-2 |
PDGFR |
platelet-derived growth factor receptor |
IGF1-R |
insulin-like growth factor 1 |
VEGFR |
vascular endothelial growth factor |
Flt3 |
fms-like tyrosine kinase 3 |
Lgr |
leucine-rich repeat-containing G-protein coupled receptor |
WNT |
wingless/integrated |
ECM |
extracellular matrix |
FAK |
focal adhesion kinase |
RAP1 |
Ras proximate 1 |
GRB2 |
growth factor receptor-bound protein 2 |
EMT |
epithelial-mesenchymal transition |
MyD88 |
myeloid differentiation factor 88 |
IRAK |
IL-1 receptor–associated kinase |
IL |
interleukin |
ACP |
actin capping protein |
PI3K |
phosphoinositide 3-kinase |
AKT |
protein kinase B |
Bcl-2 |
B-cell lymphoma 2 |
Bax |
Bcl-2-like protein 4 |
PARP |
poly (ADP-ribose) polymerase |
AMPK |
AMP-activated protein kinase |
mTOR |
mammalian target of rapamycin |
p70S6K |
ribosomal protein S6 kinase |
Smad |
small mother against decapentaplegic |
ROS |
reactive oxygen species |
KIF15 |
kinesin family member 15 |
GAP |
GTPase activating protein |
NF1 |
Neurofibtomin 1 |
RASA1 |
RAS P21 Protein Activator |
DUSP |
Dual Specificity Phosphatase |
KSR1 |
kinase suppressor of Ras-1 |
ER |
endoplasmic reticulum |
DJ-1 |
deglycase protein DJ-1 |
SOD1 |
superoxide dismutase 1 |
COX2 |
cyclooxygenase 2 |
CBLB |
casitas B-lineage lymphoma proto-oncogene-b |
MKK |
effectors mitogen activated kinase kinase |
eIF4E |
eukaryotic translation initiation factor 4E |
BMP4 |
bone-morphogenetic protein 4 |
tmTNF-α |
transmembrane tumor necrosis factor-α |
RIP3 |
receptor-interacting protein 3 |
CDC37 |
cells division cycle 37 homolog |
HSP90 |
heat shock protein 90 |
FOXO1 |
O-class forkhead factor |
IQGAP |
Ras GTPase-activating-like protein |
FGFR4 |
fibroblast growth factor receptor 4 |
HK2 |
hexokinase 2 |
Drp1 |
dynamin-related protein 1 |
Ell3 |
RNA polymerase II elongation factor |
NID1 |
nidogen 1 |
CTGF |
connective tissue growth factor |
CXCR |
C-X-C chemokine receptor |
hERG1 |
human ether-‘a-go-go related gene 1 |
JAK2 |
Janus kinase 2 |
LPP |
lipoma-preferred partner |
IGFBP2 |
insulin-like growth factor binding protein-2 |
TGF-β |
transforming growth factor-β |
IL-6R |
interleukin 6 receptor |
GP130 |
glycoprotein 130 |
Bad |
Bcl-2-associated death promoter |
HMGB1 |
high mobility group box 1 protein |
DAMP |
danger-associate molecule pattern |
RAGE |
receptor for advanced glycation end product |
ABC |
ATP binding cassette |
Pgp |
P-glycoprotein |
MRP |
multidrug resistance related protein |
BCRP |
breast cancer resistance protein |
HIF-1α |
hypoxia-inducible factor-1α |
GPR55 |
G protein-coupled receptor 55 |
G-CSF |
granulocytic-colony stimulating factor |
Sorcin |
soluble resistance-related calcium binding protein |
ABCB5 |
ATP binding cassette subfamily B member 5 |
TKI |
tyrosine kinase inhibitor |
DC |
dendritc cells |
TAM |
tumor-associated macrophage |
TIL |
T-infiltrating lymphocyte |
NK |
natural killer |
MHC |
major hystocompability complex |
ICP |
immune checkpoint |
Treg |
T-regulatory cell |
MDSC |
myeloid-derived suppressor cell |
PD-1L |
programmed death-1 ligand |
IDO |
indoleamine 2,3 dioxygenase |
CXCL |
chemokine ligand |
LAG-3 |
lymphocyte-activation gene 3 |
EML4 |
echinoderm microtubule associated protein-like 4 |
ALK |
anaplastic lymphoma kinase |
NKG2D |
NK group 2 member D |
CTLA-4 |
cytotoxic T-Lymphocyte antigen 4 |
TIM3 |
T-cell immunoglobulin mucin 3 |
TCR |
T-cell receptor |
DGK-α |
diacylglycerol kinase-α |
HBsAg |
hepatitis B surface antigen |
AIMP1 |
aminoacyl-tRNA synthetase-interacting multifunctional protein 1 |
PKC |
protein kinase C |
Th17 |
T-helper 17 |
FPPS |
farnesyl pyrophosphate synthase |
CSF-1R |
colony stimulating factor-1 receptor |