Figure 2.

Ingenuity Pathway Analysis^® (IPA) functional annotation of altered DNA methylation at loci that are involved in (a) synaptic depression, (b) neuritogenesis and neuronal development, (c) pathogenesis of neurological diseases, and (d) lipid metabolism and molecular transport, including endocytosis. Red-filled and green-filled shapes indicate increased and decreased methylation, respectively. Orange-red lines indicate activation; blue lines indicate inhibition; yellow lines indicate findings inconsistent with the state of downstream activity; grey lines indicate that the effect was not predicted.