Table 3.
Overlapping canonical pathways of the P15 DNA methylome and P15 microarray datasets.
| Methylome Analysis | Microarray Analysis | |||
|---|---|---|---|---|
| Ingenuity Canonical Pathways | p-value | Differentially Methylated Genes | p-value | Differentially Expressed Genes |
| Nitric Oxide Signaling in the Cardiovascular System | 0.002 | CACNA1C, PRKAR1B, PDE2A, GUCY2C | 0.000 | ITPR2, PIK3R3, KDR, PTPN11, PRKAA1, GUCY2D, ITPR1, CAMK4, PRKAG1, PDE2A, PDGFC |
| Cellular Effects of Sildenafil (Viagra) | 0.004 | CACNA1C, PRKAR1B, PDE2A, GUCY2C | 0.000 | MYH3, CACNG8, ITPR2, ADCY3, GPR37, GUCY2D, ITPR1, ADCY2, PLCE1, CAMK4, PRKAG1, PDE2A |
| Cardiac β-Adrenergic Signaling | 0.005 | CACNA1C, PRKAR1B, PDE2A, PDE6C | 0.036 | ADCY3, PKIG, ADCY2, PRKAG1, PDE2A, PPP2R2A, PPP1R11 |
| cAMP-Mediated Signaling | 0.005 | CAMK2B, MC3R, PRKAR1B, PDE2A, PDE6C | 0.000 | GABBR1, CHRM3, CAMK4, VIPR1, PDE2A, Htr5b, CHRM2, CNGA2, CAMK2A, GNAI3, ADCY3, HRH3, PKIG, ADCY2, LHCGR, OPRM1, GRM6 |
| Axonal Guidance Signaling | 0.006 | ARHGEF15, ITSN1, SLIT3, MKNK1, PRKAR1B, EPHB1, SRGAP2 | 0.003 | CXCL12, PIK3R3, TUBB, EPHA3, ROBO1, PLCE1, DPYSL5, RTN4R, RTN4, GNAI3, FZD4, PDGFC, BAIAP2, SEMA4F, CXCR4, NRAS, CFL1, PTPN11, NTRK2, PRKAG1 |
| Relaxin Signaling | 0.007 | PRKAR1B, PDE2A, GUCY2C, PDE6C | 0.008 | PIK3R3, ADCY3, PTPN11, GUCY2D, ADCY2, PRKAG1, PDE2A, NFKBIA, GNAI3 |
| Reelin Signaling in Neurons | 0.010 | ARHGEF15, ARHGEF3, MAP3K11 | 0.004 | PAFAH1B1, PIK3R3, PTPN11, APP, MAPT, ARHGEF9, APBB1 |
| G-Protein Coupled Receptor Signaling | 0.011 | CAMK2B, MC3R, PRKAR1B, PDE2A, PDE6C | 0.000 | PIK3R3, GABBR1, CHRM3, CAMK4, VIPR1, PDE2A, Htr5b, NFKBIA, CHRM2, CAMK2A, GNAI3, NRAS, PDPK1, ADCY3, HRH3, PTPN11, ADCY2, PRKAG1, GRM5, LHCGR, OPRM1, GRM6 |
| Protein Kinase A Signaling | 0.013 | CAMK2B, Ptpn14, TNNI1, PRKAR1B, PDE2A, PDE6C | 0.000 | ITPR2, PLCE1, NFKBIA, CNGA2, GNAI3, PYGB, ADCY3, PTPN11, ITPR1, ADCY2, PTPRF, TGFBR1, PPP1R1B, YWHAB, PPP1R11, DUSP12, PTPRN, CDC25A, PTPN2, PTPRO, H3F3A/H3F3B, CAMK4, PDE2A, PTPN23, CAMK2A, BAD, DUSP5, PTPN12, PRKAG1 |
| Breast Cancer Regulation by Stathmin1 | 0.017 | CAMK2B, ARHGEF15, ARHGEF3, PRKAR1B | 0.000 | ITPR2, PIK3R3, TUBB, CAMK4, PPP2R2A, CAMK2A, GNAI3, STMN1, NRAS, ADCY3, PTPN11, ITPR1, ADCY2, ARHGEF9, PRKAG1, PPP1R11 |
| Synaptic Long-Term Potentiation | 0.021 | CAMK2B, CACNA1C, PRKAR1B | 0.000 | NRAS, ITPR2, GRINA, ITPR1, PLCE1, CAMK4, PRKAG1, GRM5, GRIN1, CAMK2A, GRM6, PPP1R11 |
| Gustation Pathway | 0.023 | PRKAR1B, PDE2A, PDE6C | 0.000 | CACNG8, ITPR2, ADCY3, CACNB4, CACNA2D1, P2RX5, ITPR1, ADCY2, PRKAG1, PDE2A, P2RY1, CACNA1H |
| Sperm Motility | 0.023 | MAP3K11, PRKAR1B, PDE2A | 0.002 | ITPR2, PAFAH1B1, ITPR1, PLCE1, CAMK4, PRKAG1, PDE2A, CNGA2, CACNA1H |
| GNRH Signaling | 0.032 | CAMK2B, MAP3K11, PRKAR1B | 0.000 | CACNG8, ITPR2, CACNB4, CAMK4, CAMK2A, GNAI3, CACNA1H, NRAS, ADCY3, CACNA2D1, GNRHR, ITPR1, ADCY2, PRKAG1 |
| Signaling by Rho Family GTPases | 0.034 | ARHGEF15, ARHGEF3, MAP3K11, EZR | 0.010 | BAIAP2, CFL1, RHOT2, PIK3R3, PTPN11, RHOB, CDH1, ARHGEF9, PLD1, RHOV, GNAI3, STMN1 |
| Molecular Mechanisms of Cancer | 0.042 | CAMK2B, ARHGEF15, ARHGEF3, JAK3, PRKAR1B | 0.000 | RASGRF1, RHOT2, PIK3R3, CDC25A, CASP9, NFKBIA, CAMK2A, BAD, GNAI3, FZD4, NCSTN, NRAS, RALBP1, ADCY3, PTPN11, RHOB, HIF1A, ADCY2, CASP3, TGFBR1, CDH1, ARHGEF9, PRKAG1, RHOV |
| Melatonin Signaling | 0.048 | CAMK2B, PRKAR1B | 0.021 | PLCE1, CAMK4, PRKAG1, CAMK2A, GNAI3 |
| Ephrin B Signaling | 0.049 | ITSN1, EPHB1 | 0.022 | CXCL12, CXCR4, CFL1, CAP1, GNAI3 |