Table 4.
IPA annotated functional similarity between the DNA methylome and transcriptome of the P15 ID rat hippocampus.
| Category | Diseases or Functions Annotation | p-value | Differentially Methylated Genes | p-value | Number of Genes |
|---|---|---|---|---|---|
| Cell-To-Cell Signaling | Synaptic Depression/Neurotransmission | 1.65E-04 | CAMK2B, ARF1, ITSN1, DGKI, PRKAR1B, EPHB1 | 1.94E-10 | 21 |
| Nervous System Development and Function | Neuritogenesis/Extension of Neurites | 8.40E-03 | CAMK2B, ST8SIA1, ITSN1, SS18L1, BCL11B, EZR, SLIT3, UST, EPHB1, SRGAP2 | 4.92E-16 | 62 |
| Behavior | Locomotion | 3.09E-04 | RASD2, HINT1, MC3R, BTBD9, NCF1, CACNA1C, JPH3, FIG4, TAL1 | 1.08E-13 | 40 |
| Learning | 2.22E-02 | CAMK2B, NCF1, BTBD9, DGKI, CACNA1C, PRKAR1B, JPH3 | 3.51E-21 | 57 | |
| Neurological Disease | Cell Death of Cerebral Cortex Cells | 1.33E-02 | ST8SIA1, ITSN1, MAP3K11, NCF1, SH3PXD2A | 8.55E-14 | 32 |
| Movement Disorder | 4.68E-02 | CAMK2B, AEBP1, CDS1, ST8SIA1, HINT1, BCL11B, TFAP2B, PDE6C, USP36, RASD2, MC3R, BTBD9, CACNA1C | 5.58E-32 | 117 | |
| Lipid Metabolism | Quantity of Sphingolipid/Steroid | 2.73E-03 | ST8SIA1, HINT1, BCL11B, PON2 | 4.24E-09 | 40 |
| Molecular Transport | Quantity of Heavy Metal | 1.13E-02 | ARF1, USF2, COMMD1 | 4.32E-19 | 58 |
| Transport of Molecule | 1.92E-02 | SLC5A1, SLC38A1 | 5.41E-31 | 144 |