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. 2019 May 14;20(10):2380. doi: 10.3390/ijms20102380

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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LCN2 is important for MCs capacity to defend against E. coli. mMCs derived from WT, Camp^-/-, and Lcn2^-/- mice were conditioned with PBS or 200nM S1P for 48 hr, and mMC-CMs were collected for antimicrobial liquid assays against E. coli. (a) Baseline antimicrobial activity of WT, Camp^-/- or Lcn2^-/- derived mMC-CM against E. coli and (b) anti-E. coli inhibition activity of Camp^-/- or Lcn2^-/- derived mMC+PBS or +S1P. Bacteria growth was measured by OD600. Data was shown by E. coli inhibition % calculated by the formula shown in materials and methods. (c) Camp expression measured by RT-qPCR among mMCs derived from WT, Lcn2^-/- and Camp^-/- mice with PBS or 200nM S1P stimulation. *: p < 0.05, **: p < 0.01, ***: p < 0.001.