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Schematic drawing presenting changes in the organization of cortical (A) and nuclear lens (B) lipid membranes as functions of age and cholesterol/phospholipid (CHOL/PL) molar ratio in lens membranes. Note that the cholesterol content and size of the CBDs change with age. Also, in the group of 61–70-year-old donors, some of the cholesterol in the nuclear fiber cells formed cholesterol crystals. The shading of domains indicates changes in CBDs size. Adapted from [23].
