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. 2019 May 10;16(5):675–685. doi: 10.7150/ijms.32962

Figure 1.

Figure 1

Experimental procedure outline. Treadmill exercise preconditioning (EP+) was performed in Sprague-Dawley rats 3 weeks before middle cerebral artery occlusion (MCAO). The filament was removed after 60 min of MCAO to allow reperfusion. At the onset of reperfusion, separated groups of rats were given intracortical injections of 12.5 μg of siRNA-HSP72 or siRNA-vector. Three days after MCAO, neurological function tests, brain water content, Evans blue dye extravasation, and immunohistological examinations were performed.