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Additive antitumor effects of combo therapy. Groups of 8 mice that had been inoculated subcutaneously with B16F10 cells (106) at day 0. Groups of B16F10 tumor-bearing mice were orally administrated with EPA (25 mg/kg) at day 7 followed by 5-FU (40 mg/kg) treatment on days 9, 11, and 13, or with either treatment alone. (A) The tumor volume was measured. (B) Kaplan-Meier survival curves of the mice bearing B16F10 tumors. (* P < 0.05, ** P < 0.01).
