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. 2019 May 20;20(10):2490. doi: 10.3390/ijms20102490

Figure 1.

Figure 1

DNCB (2,4-dinitrochlorobenzene) induces atopic dermatitis (AD)-like lesions. (A) BALB/C mice were treated with 0.5% DNCB in acetone/olive oil (3:1) on days 1–3. Then, mice were challenged with 1% DNCB on days 14, 17, 20, 23, 26, and 29. AD-like lesions were treated with spilanthol (SP) (5 mg/kg or 10 mg/kg) or vehicle on days 14–27. Mice were sacrificed on day 30. (B) Clinical features of AD-like skin lesions treated topically with SP. (C) SP attenuates ear swelling by day 30 in DNCB-induced AD-like ear lesions. Data are presented as mean ± SEM (n = 8 mice/group). *p < 0.05, versus DNCB mice.