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SP inhibits mast cell infiltration and modulates cytokine levels in DNCB-induced AD-like skin and ear lesions. Mast cell infiltration (red arrows) stained with toluidine blue in (A) ear and (B) dorsal skin sections. (C) Mast cells measured under 10–15 high-power fields (HPFs) in ear and (D) dorsal skin. (E) Serum levels of IgE, IgG1, and IgG2 measured using ELISA. Data presented as mean ± SEM (n = 8 mice/group). * p < 0.05, ** p < 0.01 versus DNCB mice.
