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. 2019 May 20;20(10):2477. doi: 10.3390/ijms20102477

Figure 1.

Figure 1

Effect of thrombin priming on neuroprotective efficacy of mesenchymal stem cells (MSCs) in vitro oxygen–glucose deprivation (OGD)-induced primary cultured rat cortical neurons. (A) Cell viability, expressed as relative proliferation rate (%) to normal control group; (B) cytotoxicity, expressed as relative lactate dehydrogenase (LDH) release (%) to positive control (100% fully killed cells); (C) malondialdehyde (MDA) level; and (E) the number of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells captured using fluorescent microscopy (D) green, original magnification; ×400, scale bars; 20 μm) evaluated in the rat cortical neurons 24 h after co-culture with fibroblasts, naïve MSCs, or thrombin-primed MSCs (n = 6/group). Data are expressed mean ± SD. * p < 0.05 vs. normal control. # p < 0.05 vs. OGD control. $ p < 0.05 vs. OGD + fibroblasts. % p < 0.05 vs. OGD+naïve MSCs.