Table 4.
Overrepresented pathways in the collagen (COL) group after 12 weeks of resistance training and supplementation. Main categories are shown with the number of annotated pathways and downstream pathways with the calculated fold enrichment and false discovery rate (FDR).
| Pathway | Number of Pathways | Fold Enrichment | FDR |
|---|---|---|---|
| Cell Cycle | 47 | ||
| Signal Transduction | 31 | ||
| PIP3 activates AKT signaling | 3.98 | 3.56 × 10−3 | |
| MAPK family signaling cascades | 5.22 | 7.42 × 10−6 | |
| MAPK6/MAPK4 signaling | 9.65 | 1.47 × 10−5 | |
| MAPK1/MAPK3 signaling | 6.09 | 1.63 × 10−6 | |
| RAF/MAP kinase cascade | 6.22 | 1.37 × 10−6 | |
| Regulation of RAS by GAPs | 12.63 | 2.48 × 10−6 | |
| Immune System | 27 | ||
| MAP kinase activation | 7.57 | 7.58 × 10−3 | |
| Cytokine signaling in immune system | 3.71 | 7.00 × 10−7 | |
| Signaling by Interleukins | 4.25 | 2.51 × 10−6 | |
| Interleukin-1 family signaling | 7.66 | 8.30 × 10−6 | |
| Interleukin-1 signaling | 10.39 | 8.47 × 10−7 | |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | 17.89 | 9.74 × 10−3 | |
| Interleukin-12 family signaling | 6.70 | 3.23 × 10−2 | |
| Metabolism of Proteins | 23 | ||
| Translation | 3.91 | 1.13 × 10−3 | |
| Eukaryotic translation elongation | 9.14 | 2.11 × 10−5 | |
| Eukaryotic translation initiation | 6.42 | 7.41 × 10−4 | |
| Eukaryotic translation termination | 6.16 | 6.39 × 10−3 | |
| Protein folding | 7.63 | 2.41 × 10−4 | |
| Post-chaperonin tubulin folding pathway | 17.35 | 1.79 × 10−3 | |
| Cooperation of prefoldin and TriC/CCT in actin and tubulin folding | 17.89 | 3.86 × 10−5 | |
| Formation of tubulin folding intermediates by CCT/TriC | 19.09 | 1.90 × 10−4 | |
| Prefoldin mediated transfer of substrate to CCT/TriC | 21.21 | 1.74 × 10−5 | |
| Post-translational protein modification | 2.61 | 1.89 × 10−6 | |
| UCH proteinases | 11.93 | 1.04 × 10−7 | |
| Deubiquitination | 5.08 | 1.00 × 10−5 | |
| Metabolism | 15 | ||
| The citric acid (TCA) cycle and respiratory electron transport | 8.27 | 1.08 × 10−7 | |
| Pyruvate metabolism and citric acid (TCA) cycle | 8.84 | 4.29 × 10−3 | |
| Pyruvate metabolism | 12.72 | 4.76 × 10−3 | |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins | 7.76 | 2.13 × 10−5 | |
| Respiratory electron transport | 7.63 | 2.42 × 10−4 | |
| Metabolism of amino acids and derivatives | 6.8 | 4.19 × 10−11 | |
| Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism | 10.37 | 2.29 × 10−3 | |
| Glyoxylate metabolism and glycine degradation | 12.31 | 5.25 × 10−3 | |
| Gluconeogenesis | 11.57 | 6.32 × 10−3 | |
| Cellular Response to external stimuli | 11 | ||
| Cellular responses to stress | 6.31 | 1.04 × 10−10 | |
| Cellular response to hypoxia | 12.72 | 7.28 × 10−7 | |
| Oxygen-dependent proline hydroxylation of HIF-1α | 14.46 | 3.37 × 10−7 | |
| Cellular response to heat stress | 13.16 | 5.52 × 10−8 | |
| HSF1 activation | 39.77 | 1.15 × 10−5 | |
| HSF1-dependent transactivation | 31.81 | 9.12 × 10−8 | |
| Attenuation phase | 34.08 | 1.98 × 10−5 | |
| Regulation of HSF1-mediated heat shock response | 7.12 | 9.56 × 10−3 | |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) | 13.63 | 6.36 × 10−6 | |
| Metabolism of mRNA | 11 | ||
| Developmental Biology | 6 | ||
| Gene Expression | 6 | ||
| Muscle Contraction | 3 | ||
| Striated muscle contraction | 23.86 | 8.26 × 10−8 | |
| Smooth muscle contraction | 10.91 | 7.55 × 10−3 | |
| Others | 12 | ||
| CREB phosphorylation through the activation of CaMKII | 19.09 | 5.28 × 10−3 |