Skip to main content
. Author manuscript; available in PMC: 2019 Dec 13.
Published in final edited form as: Compr Physiol. 2018 Dec 13;9(1):439–455. doi: 10.1002/cphy.c180028

Figure 2.

Figure 2.

Enhancers vs Promoters

A) Enhancers function independent of orientation. If an enhancer is flipped, it maintains its gene regulation function. A flipped promoter, however, will block gene transcription.

B) Enhancers function independent of location. An enhancer that is moved downstream or upstream remains functional. A promoter that is no longer directly adjacent to the TSS will not drive transcription.

Teaching point: Enhancers function independent of orientation and location, unlike promoters.