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Enhancers and RNA polymerase II
Proteins, such as Paf1, JMDJ6, BRD4 or others, bind enhancers, and promote PTEFb-mediated phosphorylation of NELF (negative elongation factor), DSIF (DRB sensitive inducing factor) and RNA pol II. RNA pol II is released, and transcriptional elongation occurs.
Teaching point: Enhancers interact with proteins allowing conversion from transcriptional initiation to elongation.
