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. Author manuscript; available in PMC: 2019 Dec 13.
Published in final edited form as: Compr Physiol. 2018 Dec 13;9(1):439–455. doi: 10.1002/cphy.c180028

Figure 5.

Figure 5.

eRNAs

A) ChIP-Seq analysis identifies eRNA producing enhancers by enrichment for H3K27Ac and RNA pol II

B) Model of eRNA function at Nanog function. eRNAs appear to facilitate or stabilize chromatin loops between specific enhancer:gene promoter combinations.

Teaching Point: eRNAs can be identified through ChIP-Seq analysis and may play a role in regulation gene expression changes