Figure 5.
eRNAs
A) ChIP-Seq analysis identifies eRNA producing enhancers by enrichment for H3K27Ac and RNA pol II
B) Model of eRNA function at Nanog function. eRNAs appear to facilitate or stabilize chromatin loops between specific enhancer:gene promoter combinations.
Teaching Point: eRNAs can be identified through ChIP-Seq analysis and may play a role in regulation gene expression changes