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. 2019 May 17;20(10):2443. doi: 10.3390/ijms20102443

Figure 4.

Figure 4

MOD treatment increases the sensitivity of cisplatin in CRC through downregulation of DCLRE1B. (A) Differentially expressed genes (DEGs) between non-treated and MOD treated A2780cis cells were represented in a heatmap. The 31 genes were identified as DEGs. Expression of 14 genes increased and 17 genes decreased in MOD treated cells using a cutoff standard of FC > |1.5| and p-value < 0.05. After treatment of A2780cis cells with MOD in various concentration (0 and 160 μg/mL) for 48 h, (B) DCLRE1B mRNA expression, (C) transfection of A2780cis with control siRNA (siCONT) and DCLRE1B-targeting siRNA (siDCLRE1B) followed by cisplatin treatment for 48 h. Cell viability was measured with MTT assays. Data are shown as the mean ± STDEV. Significant differences between non-treated and treated groups was assessed using the Student’s t-test. * p < 0.05 was used to define statistical significance. NS: not significant.