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. 2019 Apr 27;11(5):968. doi: 10.3390/nu11050968

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Matrix-assisted laser desorption ionization mass spectrometry imaging performed in negative ion mode followed by principal component analysis. The first discriminant function is shown. (A) 6-d UP group animals showed an altered lipid profile compared to the other treatment groups, (B) with a higher abundance of m/z 885.58 PI 38:4 [M−H]⁻ and a reduced presence of m/z 498.29 [M−H]⁻ dihydroxy BA TCDA/TCDCA and m/z 514.29 [M−H]⁻ trihydroxy BA TCA. (C–F) In the 6-d UP + sterol and 6-d UP + sterol + carrier groups, UP-induced lipidome and BA changes were partially prevented with a profile comparable to the controls. Abbreviations: BA, bile acid; PI, phosphatidylinositol; TCA, taurocholic acid; TCDA, taurodeoxycholic acid; TCDCA, taurochenodeoxycholic; UP, U. parvum.