. 2019 May 20;20(10):2488. doi: 10.3390/ijms20102488

Table 1.

GPCRs modulating TRPV1 function.

GPCR Ligand	Involved GPCR	Pathway	Effect on TRPV1	Reference
Bradykinin	B $_{2}$	G $α_{q}$ -DAG-PKC	increased current	[2,41]
Serotonin	5-HT $_{2}$	G $α_{q}$ -DAG-PKC	increased current	[42,43,44]
	5-HT $_{4}$	G $α_{s}$ -AC-PKA	increased current	[43]
	5-HT $_{7}$	G $α_{s}$ -AC-PKA	increased current	[42]
UTP	P2Y $_{2}$	G $α_{q}$ -DAG-PKC	increased current	[45,46,47]
BAM 8-22	MRGPRX1	G $α_{q}$ -DAG-PKC-PIP $_{2}$	increased current	[48]
Proteases	PAR2	G $α_{q}$ -PKC	increased current	[49,50]
	PAR1	G $α_{q}$ -PKC	increased current	[51]
	PAR4	G $α_{q}$ -PKC	increased current	[51]
PGE $_{2}$	EP $_{1}$	G $α_{q}$ -PKC	increased current	[52]
	EP $_{2}$	G $α_{s}$ -PKA	increased current	[52,53,54]
PGI $_{2}$	IP	G $α_{q}$ -PKC	increased current	[52]
	IP	G $α_{s}$ -PKA	increased current	[52]
Endothelin-1	ET $_{A}$	G $α_{q}$ -PKC	increased current	[55,56]
Substance P	NK $_{1}$	G $α_{q}$ -PKC $ϵ$	increased current	[57]
	NK $_{2}$	G $α_{q}$ -PKC	increased current	[58]
H $^{+}$	TDAG8 (GPR65)	G $α_{s}$ -PKA	increased current	[59]
Morphine	MOP	G $α_{i}$ -reduced AC	decreased current	[60,61]
Endocannabinoids	CB $_{1}$	G $α_{i}$ -reduced AC	decreased current	[62]
	CB $_{2}$	G $α_{i}$ -reduced AC	decreased current	[63]

AC, adenylyl cylcase; DAG, diacylglycerol; PKA, proteinkinase A; PKC, protein kinase C; BAM 8–22, bovine adrenal medulla peptide 8–22.