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. 2019 May 20;20(10):2480. doi: 10.3390/ijms20102480

Figure 2.

Figure 2

JMV-1843 attenuates seizures in the D1R-mediated kindling model. (A) Maximal behavioral score was lower in JMV-1843 treated mice (n = 11) compared to saline-treated controls (n = 10). Two-way RM ANOVA (Interaction p > 0.05, F(4,76) = 0.5059; Time p < 0.0001, F(4,76) = 11.87; Treatment p < 0.001, F(1,19) = 18.85). (B) The number of hippocampal seizures on EEG recordings was lower in JMV-1843 (n = 9) treated mice compared to saline-treated controls (n = 7). Mann–Whitney test (p < 0.01; Mann–Whitney U = 3.500). (C) Total seizure duration was lower in JMV-1843 treated mice (n = 9) compared to controls (n = 7). Mann–Whitney test (p < 0.05; Mann–Whitney U = 11.00). (D) Average seizure duration did not differ between JMV-1843 treated mice (n = 9) and controls (n = 7). Mann–Whitney test (p > 0.05; Mann–Whitney U = 30.00). (E) Representative trace of JMV-1843-treated mouse during SKF 5th. 0.3 Hz high-pass, 60 Hz low-pass, and 50 Hz power line filters were applied. Data are presented as mean ± SEM. * p < 0.05; ** p < 0.01. EEG, electro-encephalography; µV, microvolt; mV, millivolt; min, minute; s, second; SKF, SKF81297.