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. 2019 May 20;20(10):2480. doi: 10.3390/ijms20102480

Figure 4.

Figure 4

The effect of YIL781 on SKF81297 induced seizures. (A) Maximal behavioral scores obtained by YIL781-treated (n = 6) and control (n = 6) animals. Two-way RM ANOVA (interaction p > 0.05, F(4,40) = 1.035; time p < 0.05, F(4,40) = 3.597; treatment p > 0.05, F(1,10) = 3.071). (B) The number of hippocampal seizures on EEG did not differ between YIL781-treated mice (n = 4) and saline-treated control mice (n = 5). Mann–Whitney test (p = 0.056; Mann–Whitney U = 2.000). (C) Total seizure duration was higher in YIL781 treated mice (n = 5) compared to saline-treated control mice (n = 4). Mann–Whitney test (p < 0.05; Mann–Whitney U = 0.0). (D) YIL781-treated mice (n = 5) have higher average seizure durations compared to saline-treated control mice (n = 4). Mann–Whitney test (p < 0.05; Mann–Whitney U = 0.0). (E) Representative traces of YIL781-treated mouse already experiencing several seizures during SKF 3rd. 0.3 Hz high-pass, 60 Hz low-pass, and 50 Hz power line filters were applied. Data are presented as mean ± SEM. *, p < 0.05. EEG, electro-encephalography; µV, microvolt; mV, millivolt; min, minute; s, second; SKF, SKF81297.