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. 2019 May 20;20(10):2480. doi: 10.3390/ijms20102480

Figure 6.

Figure 6

The effect of JMV-2959 on SKF81297 induced seizures. (A) Maximal behavioral scores obtained by JMV-2959-treated (n = 7) and control (n = 8) animals. Two-way RM ANOVA (interaction p > 0.05, F(4,52) = 0.8936; time p < 0.05, F(4,52) = 3.263; treatment p > 0.05, F(1,13) = 1.525). (B) The number of hippocampal seizures on EEG did not differ between JMV-2959-treated mice (n = 5) and saline-treated control mice (n = 5). Mann–Whitney test (p > 0.05; Mann–Whitney U = 9.000). (C) Total seizure duration did not differ between JMV-2959-treated mice (n = 5) and saline-treated control mice (n = 5). (D) JMV-2959-treated mice (n = 5) did not differ in average seizure duration compared to saline-treated control mice (n = 5). Mann–Whitney test (p < 0.05; Mann–Whitney U = 12.00). (E) Representative trace of JMV-2959-treated mouse during SKF 5th. 0.3 Hz high-pass, 60 Hz low-pass, and 50 Hz power line filters were applied. Data are presented as mean ± SEM. EEG, electro-encephalography; µV, microvolt; mV, millivolt; min, minute; s, second; SKF, SKF81297.