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Signaling pathways employed by JMV-1843, YIL781, and JMV-2959. An arrow upwards denotes activation of a pathway by binding of a ghrelin-R ligand. A hyphen denotes no alterations in basal signaling levels induced by binding of a ghrelin-R ligand. YIL781 and JMV-2959 are both not able to recruit β-arrestin.
| JMV-1843 | YIL781 | JMV-2959 | |
|---|---|---|---|
| Gαq/11 | ↑ | ↑ | – |
| Gαi/o | ↑ | – | – |
| Gα12 | ↑ | ↑ | – |
| Gα13 | ↑ | – | – |
| β-arrestin | ↑ | – | – |
