Table 1.

Primary and secondary outcome measurements for the treatment with Saffron vs. Fluoxetine.

Questionnaire	Weeks into Treatment	Treatment Group
		Saffron			Fluoxetine
		Mean	SD	p-Value *	Mean	SD	p-Value *
IBS-Qol	Baseline	60.00	9.15		59.18	7.28
	2 weeks	60.61	8.07	0.033	59.27	6.21	0.753
	4 weeks	62.36	7.27	<0.001	61.33	6.74	<0.001
	6 weeks	68.06	7.00	<0.001	67.36	7.58	<0.001
HADS-Depression domain	Baseline	7.48	1.80		7.88	1.85
	2 weeks	7.36	1.52	0.525	7.45	1.64	<0.001
	4 weeks	6.58	1.23	<0.001	6.76	1.12	<0.001
	6 weeks	5.91	0.98	<0.001	6.21	0.86	<0.001
HADS-Anxiety domain	Baseline	7.27	1.72		7.45	1.60
	2 weeks	7.03	1.76	0.058	7.61	1.34	0.201
	4 weeks	6.79	1.62	0.001	7.39	1.30	0.690
	6 weeks	6.55	1.50	<0.001	6.94	0.90	0.019

SD = standard deviation, IBS = irritable bowel syndrome, QoL = quality of life, HADS = Hospital Anxiety and Depression Scale * p-values are for paired sample t-tests comparing values to their baseline amount.