Figure 4.

Unique pathways activated by differentially secreted adipokines. The prediction of secretory protein classification as classical SP+/SP− signaling sequences or non-classically secreted proteins was performed with SignalP 4.1 or SecretomeP 2.0, as indicated in the methods section. The functional annotation of differentially abundant proteins was performed separately on (A) proteins with classical SP+/SP− signaling sequences and (B) non-classically secreted proteins. Abbreviations: AA: amino acids, BCAA: branched chain amino acids; ECM: extracellular matrix; FA: fatty acids; n.d.: not detected, TCA cycle: tricarboxylic acid cycle.