Table 7.

Carotenoid plasma concentrations during 4-week treatment with TNC containing 2, 5 and 15 mg lycopene.

Carotenoid Plasma Concentration (µM)	Baseline Mean ± SD	Week 2 Mean ± SD (p) 1	Week 3 Mean ± SD (p) 1	Week 4 Mean ± SD (p) 1
Lycopene
TNC 2 mg 2	1.021 ± 0.437	1.483 ± 0.481 (0.001)	1.354 ± 0.408 (0.009)	1.656 ± 0.537 (<0.000x)
TNC 5 mg 2	1.149 ± 0.322	1.629 ± 0.444 (<0.000x)	1.677 ± 0.470 (<0.000x)	1.767 ± 0.473 (<0.000x)
TNC 15 mg 2	1.036 ± 0.398	1.794 ± 0.453 (<0.000x)	1.754 ± 0.449 (<0.000x)	2.008 ± 0.627 (<0.000x)
Phytofluene
TNC 2 mg 2	0.310 ± 0.147	0.382 ± 0.211 (0.171)	0.300 ± 0.126 (0.805)	0.398 ± 0.242 (0.128)
TNC 5 mg 2	0.354 ± 0.130	0.429 ± 0.190 (0.120)	0.456 ± 0.201 (0.046)	0.530 ± 0.263 (0.005)
TNC 15 mg 2	0.270 ± 0.111	0.503 ± 0.235 (<0.000x)	0.536 ± 0.228 (<0.000x)	0.650 ± 0.275 (<0.000x)
Phytoene
TNC 2 mg 2	0.057 ± 0.040	0.073 ± 0.060 (0.300)	0.059 ± 0.037 (0.868)	0.091 ± 0.061 (0.028)
TNC 5 mg 2	0.046 ± 0.032	0.096 ± 0.050 (<0.000x)	0.092 ± 0.057 (0.001)	0.124 ± 0.058 (<0.000x)
TNC 15 mg 2	0.048 ± 0.031	0.133 ± 0.062 (<0.000x)	0.127 ± 0.068 (<0.000x)	0.158 ± 0.091 (<0.000x)
β-carotene
TNC 2 mg 2	0.842 ± 0.391	0.975 ± 0.484 (0.289)	0.872 ± 0.486 (0.811)	0.998 ± 0.502 (0.224)
TNC 5 mg 2	0.947 ± 0.598	0.954 ± 0.580 (0.965)	0.919 ± 0.473 (0.866)	1.037 ± 0.533 (0.590)
TNC 15 mg 2	0.885 ± 0.534	0.968 ± 0.609 (0.618)	0.970 ± 0.553 (0.587)	1.057 ± 0.631 (0.315)

¹p-value for difference from baseline within the same dose arm. ²N = 25 for TNC 2 mg and 15 mg. N = 24 for TNC 5 mg.