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. 2019 May 17;20(10):2456. doi: 10.3390/ijms20102456

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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MOTS-c triggers thermogenic genes program via the ERK signaling pathway. (A–D) The protein levels of phospho-ERK1/2, PGC1α, and UCP1 in adipocytes treated with MOTS-c and immunoreactive bands were quantified by densitometric analysis using ImageJ (n = 4, per group). (E–G) The RNA level of thermogenic genes (PGC1α, UCP1, and Dio2) (n = 4, per group). (H–K) The level of phospho-ERK1/2, PGC1α, and UCP1 in adipocytes treated with MOTS-c and ERK inhibitor, and immunoreactive bands were quantified by densitometric analysis using ImageJ (n = 4, per group). (L–N) The RNA level of thermogenic genes (PGC1α, UCP1, and Dio2) (n = 4, per group). All data are represented as mean ± SEM. Differences between the two groups were determined by a two-tailed Student’s t-test. * p < 0.05, ** p < 0.01, *** p < 0.001, n.s. = not significant.