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. 2019 Jun 6;41(1):481–488. doi: 10.1080/0886022X.2019.1621759

Figure 2.

Figure 2.

Deletion of discoidin domain receptor 2 attenuates renal interstitial fibrosis. (A) HE staining (scale bar = 50 µm). (B) Masson staining (scale bar = 50 µm). (C) Relative normalized gene expression of COL1A1, fibronectin and α-SMA, evaluated by real-time qPCR at 14 days after the UUO operation (**p < .01, ***p < .001, ****p < .0001). (D) Relative normalized gene expression of DDR2, evaluated by real-time qPCR at 14 days after the UUO operation (****p < .0001). (E) The content of hydroxyproline in the kidney at 14 days after the UUO operation (****p < .0001). (F) Western blot analysis of the protein level of fibronectin and COL1A1 14 days after UUO in the DDR2-deficient mice and the wild-type mice.