Table 2.

Univariate and multivariate analysis of PFS and OS in all patients

Variable	Univariate		Multivariate
	PFS	0S	PFS			OS
	P	P	HR	95%CI	P	HR	95%CI	P
Sex	0.329	0.429
Male
Female
Age	0.026a	0.022a
< 50			RL			RL
≥ 50			1.894	(1.049,3.419)	0.034	1.999	(1.072,3.727)	0.029
Extent of surgery	0.003a	0.040a
PR			RL			RL
CR			0.370	(0.198,0.692)	0.002
KPS scores	0.036a	0.000a
90–100						RL
80						0.273	(0.137,0.542)	0.000
≤ 70						0.265	(0.095,0.738)	0.011
Concomitant TMZ	0.945	0.113
Yes
No
TMZ cycles	0.016a	0.000a
< 6			RL			RL
≥ 6			0.495	(0.275,0.890)	0.019	0.246	(0.124,0.488)	0.000

Abbreviations: TMZ temozolomide, PR partial resection, CR complete resection, RL referent level

^aSignificant in univariate analysis