Table 2.
Results of the in silico modelling of all missense variants in B3GAT3
| Missense variant | Location | Change in H-bonds | New clashes | Change in surface hydrophobicity | Possible effect on dimerisation | Overlap in Van Der Waals forces | Literature evidence | Total |
|---|---|---|---|---|---|---|---|---|
| p.(Pro82Leu) | Substrate donor subdomain | / | / | / | / | + | / | 1 |
| p.(Thr139Met) | Substrate donor subdomain | + (3) | + (8) | + | / | / | / | 3 |
| p.(Pro140Leu) | Substrate donor subdomain | / | / | + | / | / | / | 1 |
| p.(Gly223Ser) | Substrate acceptor subdomain | + (1) | + (6) | / | + | / | + | 4 |
| p.(Leu224Gln) | Substrate acceptor subdomain | / | + (4) | / | + | + | / | 3 |
| p.(Arg277Gln) | Substrate acceptor subdomain | / | + (2) | / | / | / | + | 2 |
/: no alteration was predicted