Table 4.
Top pathways enriched in patients with post-RT pain in breast cancer patients from DAVID functional annotation module analysis
| Cluster | Category | Term | No. genes in a term | Fold enrichment1 | p value2 | FDR3 |
|---|---|---|---|---|---|---|
| 1 | GOTERM_BP_DIRECT | GO:0052697~xenobiotic glucuronidation | 9 | 19.81952 | 3.45E-10 | 9.46E-07 |
| GOTERM_BP_DIRECT | GO:2001030~negative regulation of cellular glucuronidation | 8 | 19.81952 | 6.14E-09 | 8.43E-06 | |
| GOTERM_BP_DIRECT | GO:1904224~negative regulation of glucuronosyltransferase activity | 8 | 19.81952 | 6.14E-09 | 8.43E-06 | |
| GOTERM_BP_DIRECT | GO:0045922~negative regulation of fatty acid metabolic process | 8 | 17.61735 | 2.64E-08 | 2.42E-05 | |
| GOTERM_BP_DIRECT | GO:0052695~cellular glucuronidation | 8 | 10.57041 | 3.62E-06 | 0.001983 | |
| GOTERM_BP_DIRECT | GO:0052696~flavonoid glucuronidation | 9 | 8.494079 | 4.53E-06 | 0.002071 | |
| GOTERM_MF_DIRECT | GO:0015020~glucuronosyltransferase activity | 9 | 7.057233 | 2.18E-05 | 0.019001 | |
| GOTERM_MF_DIRECT | GO:0001972~retinoic acid binding | 8 | 6.818583 | 1.04E-04 | 0.04456 | |
| KEGG_PATHWAY | hsa00053:Ascorbate and aldarate metabolism | 9 | 6.071802 | 6.39E-05 | 0.016351 | |
| KEGG_PATHWAY | hsa00040:Pentose and glucuronate interconversions | 10 | 5.159047 | 8.29E-05 | 0.007101 | |
| KEGG_PATHWAY | hsa00860:Porphyrin and chlorophyll metabolism | 11 | 4.706058 | 7.16E-05 | 0.009189 | |
| KEGG_PATHWAY | hsa05204:Chemical carcinogenesis | 13 | 3.081485 | 8.48E-04 | 0.053271 | |
| KEGG_PATHWAY | hsa00982:Drug metabolism - cytochrome P450 | 12 | 3.189229 | 0.001097 | 0.055041 | |
| 2 | GOTERM_BP_DIRECT | GO:0050911~detection of chemical stimulus involved in sensory perception of smell | 37 | 2.020171 | 8.21E-05 | 0.031689 |
| GOTERM_MF_DIRECT | GO:0004984~olfactory receptor activity | 37 | 1.992656 | 1.09E-04 | 0.03161 | |
| KEGG_PATHWAY | hsa04740:Olfactory transduction | 36 | 1.730048 | 0.001446 | 0.060346 | |
| GOTERM_MF_DIRECT | GO:0004930~G-protein coupled receptor activity | 48 | 1.589467 | 0.0017 | 0.312315 |
1The fold enrichment is defined as the ratio of the two proportions; one is the proportion of genes in your list belong to certain pathway, and the other is the proportion of genes in the background information (i.e., universe genes) that belong to that pathway
2p values from modified Fisher’s exact test
3FDR, false discovery rate from Benjamini and Hochberg
DAVID = Database for Annotation, Visualization and Integrated Discovery, GO = Gene Ontology, KEGG = The Kyoto Encyclopedia of Genes and Genomes