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. 2019 Jun 13;10:170. doi: 10.1186/s13287-019-1278-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — microRNA profiles of UN-Exo and OD-Exo via microRNA sequencing. a MicroRNA levels in OD-Exo significantly changed when compared with that in UN-Exo, 28 microRNAs significantly changed, of which 7 increased and 21 decreased. b Four bioinformatics tools (TargetScan, miRTarBase, miRDB, and miRWalk) were used to analyze genes targeted by differentially expressed microRNAs, for example, hsa-miR-27a-5p. c All genes targeted by differentially expressed microRNAs were shown in the mRNA-microRNA network. d mRNA-microRNA network showed 16 genes in TGFβ signaling were targeted by 15 differentially expressed microRNAs. e Consistent with the microRNA sequencing, hsa-miR-5100 and hsa-miR-1260a were increased; hsa-miR-210-3p and hsa-miR-10b-5p were decreased by qPCR analysis