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. 2019 Jun 13;10:170. doi: 10.1186/s13287-019-1278-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Exosomal miR-27a-5p regulated odontogenic differentiation via TGFβ1/smads signaling pathway by downregulating LTBP1. a miR-27a-5p mimics promoted odontogenic differentiation of DPSCs by upregulating the protein expressions of DSP, DMP-1, ALP, and RUNX2. b miR-27a-5p mimics activated TGFβ1/smads signaling pathway by increasing TGFβ1, TGFR1, p-Smad2/3, and Smad4 proteins. c The western blot showed LTBP1 was downregulated bymiR-27a-5p mimics. d The predicted miRNA binding sites in the 3′-UTR of LTBP1. e Luciferase reporter assay found that miR-27a-5p could significantly reduce LTBP1-WT luciferase activity and that miR-27a-5p had no effect on the luciferase activity of LTBP1-MUT group