Table 3.

Assessment of telomere-associated SNPs.

SNP	Risk genotype	Beta	SE	p Value
rs6772228	A/T	0.83	0.37	0.001
rs6772228	A/A	0.33	0.37	0.001
rs9419958	T/T	0.61	0.56	0.036
rs9419958	C/T	0.59	0.54	0.031
rs9420907	C/C	0.59	0.53	0.021
rs9420907	A/A	0.6	0.53	0.024
rs4387287	A/A	0.71	0.16	0.014
rs4387287	A/C	0.63	0.07	0.067
rs3027234	G/G	0.62	0.07	0.009
rs3027234	A/G	0.63	0.07	0.011
rs8105767	G/A	0.66	0.08	1.29 × 10−4
rs8105767	G/G	0.91	0.07	4.89 × 10−4
rs412658	C/C	0.73	0.07	0.008
rs412658	C/T	0.69	0.06	0.058
rs6028466	G/G	0.36	0.22	0.087
rs6028466	A/G	0.37	0.22	0.088
rs755017	A/A	0.45	0.63	0.054
rs755017	A/G	0.45	0.63	0.052

Investigation of causal effect of telomere length on ALS by using nine SNPs identified by telomere length GWAS. SNPs rs8105767 (PXK) and rs6772228 (ZNF208) were associated with ALS.

SNPs highlighted in bold show association with ALS.