Table 6.
Genotype and allele frequencies of IL-β, IL17, IL10 and IL28 in influenza A (H1N1) and ILI groups
| Gene and genotype/ Allele | Flu A (H1N1) (%) | ILI (%) | Crude p value | OR (95% CI) | Adjusted P value | ||
|---|---|---|---|---|---|---|---|
| IL-1β; rs16944 | |||||||
| AA | 6(20) | 24(80) | |||||
| GA | 44(39.6) | 67(60.4) | .057 | .185 | |||
| GG | 0(0) | 4(100) | |||||
| GG vs. GA/AA | 0(0) | 50(35.5) | 4(100) | 91(64.5) | .299 | .000 (.000- NA) | .999 |
| AA vs. GG/GA | 6(20) | 44(38.3) | 24 (80) | 71(61.7) | .061 | .295 (.103–.845) | .023 |
| A | 56 (56) | 115 (60) | .456 | 1.205(.738–1.967) | |||
| G | 44 (44) | 75 (39) | |||||
| IL-17;rs2275913 | |||||||
| AA | 3(25) | 9(75) | |||||
| AG | 16(22.9) | 54(77.1) | .007* | .011* | |||
| GG | 30(48.4) | 32(51.6) | |||||
| GG vs. GA/AA | 30(48.4) | 19(23.2) | 32(51.6) | 63(76.8) | .002* | 3.072 (1.461–6.461) | .003* |
| AA vs. AG/GG | 3(25) | 46(34.8) | 9(75) | 86(65.2) | .491 | .635 (.154–2.621) | .530 |
| A | 22 | 72 | .008* | 2.108(1.207–3.682) | |||
| G | 76 | 118 | |||||
| IL-10; rs1800872 | |||||||
| GG | 3(42.9) | 4(57.1) | .851 | ||||
| TG | 44(36.4) | 77(63.6) | .575 | ||||
| TT | 3(30) | 7(70) | |||||
| TT vs. GG/TG | 3(30) | 47(36.7) | 7(70) | 81(63.3) | .670 | .774 (.183–3.277) | .728 |
| GG vs. TG/TT | 3(42.9) | 47(35.9) | 4(57.1) | 84(64.1) | .704 | .810 (.165–3.974) | .795 |
| T | 50 | 91 | .785 | 1.071(.655–1.749) | |||
| G | 50 | 85 | |||||
| IL-28; rs8099917 | |||||||
| GG | 2(33.3) | 4(66.7) | |||||
| GT | 28(36.8) | 48(63.2) | .863 | .683 | |||
| TT | 20(31.7) | 43(68.3) | |||||
| TT vs. GG/GT | 20(31.7) | 30(36.6) | 43(68.3) | 52(63.4) | .543 | .658 (.316–1.372) | .264 |
| GG vs. GT/TT | 2(33.3) | 48(34.5) | 4(66.7) | 91(65.5) | 1.000 | 1.228 (.206–7.323) | .821 |
| T | 68 | 134 | .656 | 1.126(.667–1.900) | |||
| G | 32 | 56 | |||||
OR Odds ratio, CI Confidence interval (calculated by logistic regression model)
p value is significant