Figure 6.
H2 Mechanism for preventing ALI induced by LPS. Under basal conditions, autophagy is negatively regulated by mTOR. LPS treatment increased intracellular ROS formation, which inhibited the mTOR activity by activating AMPK. Inhibition of mTOR triggered the excessive activation of autophagy and led to ALI. Pretreatment with H2 can inhibit excessive activation of autophagy after LPS treatment by scavenging intracellular ROS and ameliorate ALI. AECII: alveolar type II epithelial cell. (A color version of this figure is available in the online journal.)