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. 2019 Jun 13;10:165. doi: 10.1186/s13287-019-1262-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — GMSCs have no side effects in long-term toxicity test in rats. a GSMC influence on RBC related indexes, including hemoglobin concentration (HGB), hematocrit (HCT), erythrocyte mean corpuscular volume (MCV), mean corpuscular-hemoglobin concentration (MCHC), red blood cell distribution width (RDW), and (b) the percentage (%) of immune cells, including white blood cells (WBC), lymphocyte, monocytes (MONO), neutrophilic granulocyte (NEUT), basophilic granulocyte (BASO), eosinophilic granulocyte (EOS) by infusing GMSCs into rats in the first dose period (FP), withdrawal period (WP), and convalescence period (CP) respectively. GMSC effect on biochemical indexes (c) and H&E staining (d–e) of parts of important organ of rats. The data indicate the mean ± SD of three separated experiments. *p < 0.05, **p ≤ 0.01. N ≥ 6 rats/group