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. 2019 Jun 14;38:257. doi: 10.1186/s13046-019-1248-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Exposure of BRCA1-KO fibroblasts to cancer EVs changed their pattern of miRNA expression. a and b, PCA mapping and hierarchical clustering showed that BRCA1-KO fibroblasts exposed to cancer EVs clustered differently from non-exposed cells. In addition, EVs clustered far from cells. c, Differential miRNA expression between EVs-exposed and non-exposed cells. Data are obtained with 3 independent cell cultures. Filter criteria were set as follows: Fold change: > 2 or < − 2 and FDR P value < 0.05