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. 2019 May 7;15(6):1139–1147. doi: 10.7150/ijbs.30904

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HJURP promotes cell migration and invasion by activating Epithelial-to-Mesenchymal Transition in vitro and facilitates tumor metastasis in vivo. (A) The invasion and migration abilities were significantly decreased in HJURP-knockdown group (HJURP-KD) HCC-LM3 and Huh7(B) cells compared to the control group (NTC). (C) Representative pictures H&E staining from HJURP-KD and NTC group (n=4). Lung metastasis lesions were shown by black arrows. (D)EMT related protein (E-cadherin, Vimentin) were detected by western-blot. (E) E-cadherin (red) and Vimentin (green) were analyzed by immunofluorescence in HCC-LM3 cells (HJURP-knockdown) and Huh7 cells (HJURP-overexpression).