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. 2019 May 7;15(6):1139–1147. doi: 10.7150/ijbs.30904

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© Ivyspring International Publisher

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HJURP facilitates EMT via upregulating Sphingosine Kinase 1. (A) Microarray analysis of NTC and KD group in Huh7 cells. (B) EMT-related genes were analyzed by RT-qPCR in HCC-LM3 and Huh7 cells. Relative mRNA levels of 20 genes (left) and SPHK1 (right) are shown. (C) KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways enriched in 164 genes whose expression is correlated with HJURP. The sphingolipid metabolic progress is marked with “*”. (D) Scatter plots shows a positive correlation between HJURP and SPHK1 at the mRNA level. Data were from TCGA database. (E) The protein level of HJURP and SPHK1 were detected by western-blot in HCC-LM3 and Huh7 cells. (F) Co-Immunoprecipitation assay shows HJURP interacts with SPHK1 in HCC-LM3 cells.