Table 6.

Effective concentration and dose of molecular hydrogen against sepsis

Organ/cell	Administration	Effective concentration	References
Lung	H2 inhalation	2%	8, 13, 15, 20
	HRS 8 ml/kg i.v.	> 0.6 mmol/L	11
	HRS 10 ml/kg i.p.	> 0.6 mmol/L	14
	HRW po.	0.25-1.6 mmol/L	16
Liver	HRW po.	0.6 mmol/L	6
	HRS 8 ml/kg i.p.	> 0.6 mmol/L	21
	HRS 8 ml/kg i.v.	> 0.6 mmol/L	22
Kidney	H2 inhalation	2%	24, 25
	HRS 5 ml/kg i.p.	> 0.6 mmol/L	23
Brain	H2 inhalation	2%	26
Pancreas	HRW 6 ml/kg po.	0.62-0.82 mmol/L	27
Heart	HRS 10 ml/kg i.p.	> 0.6 mmol/L	7
Eye	HRS 10 ml/kg i.p.	> 0.6 mmol/L	10
Endothelial cell	HRM incubation	0.6 mmol/L	30, 35, 36, 38
	HRS 5 ml/kg i.p.	> 0.6 mmol/L	36
Epithelial cell	HRS 8 ml/kg gavage	0.7 mmol/L	29
	HRS 8 ml/kg i.v.	> 0.6 mmol/L	11
	HRM incubation	0.6 mmol/L	9