Table 2.
Univariate analyses of factors associated with recurrence-free survival and cancer-specific survival of CRC patients
| Factors | Recurrence-free survival | Cancer-specific survival | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| Gender (Male vs. Female) | 0.88 | 0.55-1.43 | 0.618 | 0.88 | 0.49-1.59 | 0.680 | |
| Age (<60 vs. ≥60 years) | 0.70 | 0.43-1.14 | 0.151 | 0.85 | 0.48-1.51 | 0.573 | |
| BMI (<18.5 vs.≥18.5, <25.0 vs. ≥25.0 kg/m2) | 0.88 | 0.62-1.25 | 0.478 | 0.74 | 0.48-1.15 | 0.180 | |
| Tumour location (Colon vs. Rectal) | 1.48 | 0.86-2.22 | 0.187 | 1.44 | 0.81-2.54 | 0.216 | |
| Tumour size (<5 vs. ≥5 cm) | 1.10 | 0.68-1.78 | 0.687 | 1.37 | 0.77-2.42 | 0.287 | |
| Histopathological type (Well-moderate vs. Poor) | 1.41 | 1.04-1.93 | 0.028* | 1.47 | 1.01-2.14 | 0.046* | |
| Depth of tumour invasion (T1-T2 vs. T3-T4) | 1.56 | 1.07-2.28 | 0.022* | 1.60 | 1.01-2.54 | 0.048* | |
| Lymph node metastasis (N0-1 vs. N2-3) | 1.63 | 1.30-2.06 | <0.001* | 1.62 | 1.22-2.16 | 0.001* | |
| pTNM stage (I-II vs. III) | 3.07 | 1.92-4.92 | <0.001* | 4.08 | 2.19-7.57 | <0.001* | |
| Lymphatic vessel invasion (Negative vs. Positive) | 2.18 | 1.35-3.52 | 0.002* | 2.91 | 1.61-5.29 | <0.001* | |
| Venous invasion (Negative vs. Positive) | 1.94 | 1.20-3.12 | 0.007* | 2.07 | 1.17-3.70 | 0.013* | |
| Severe complication (Absence vs. Presence) | 1.34 | 0.72-2.41 | 0.334 | 1.17 | 0.56-2.41 | 0.680 | |
| Adjuvant chemotherapy (no vs. yes) | 1.87 | 1.14-3.08 | 0.014* | 2.74 | 1.42-5.28 | 0.003* | |
| Preoperative CEA (<5 vs. ≥5 ng/ml ) | 1.50 | 0.92-2.46 | 0.108 | 1.16 | 0.63-2.15 | 0.631 | |
| Preoperative CA125 (<35 vs. ≥35 U/ml ) | 1.51 | 0.90-2.54 | 0.116 | 1.62 | 0.89-2.97 | 0.116 | |
| Preoperative CA199 (<37 vs. ≥37 U/ml) ) | 1.45 | 0.89-2.38 | 0.138 | 1.49 | 0.82-2.68 | 0.188 | |
| Preoperative CONU score (Low vs. High) | 2.79 | 1.69-4.59 | <0.001* | 4.55 | 2.35-8.81 | <0.001* | |
| Preoperative CTC staus (Negative vs. Positive) | 5.81 | 2.34-14.47 | <0.001* | 8.14 | 1.97-33.57 | 0.004* | |
| Preoperative CONUT-CTC score (0 vs. 1 vs. 2) | 2.78 | 1.88-4.13 | <0.001* | 3.96 | 2.28-6.90 | <0.001* | |
Notes: *indicates P<0.05. CRC, colorectal cancer; HR, hazard ratio; CI, confidence interval; BMI, body mass index; TNM, tumour-node-metastasis; CEA, carcinoembryonic antigen; CA125, carbohydrate antigen 125; CA199; carbohydrate antigen 199; CONUT, controlling nutritional status; CTC, circulating tumour cell.