Table 3.
Multivariate analyses of factors associated with recurrence-free survival and cancer-specific survival of CRC patients
| Factors | Recurrence-free survival | Cancer-specific survival | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| Model 1 | |||||||
| Histopathological type (Well-moderate vs. Poor) | 1.33 | 0.97-1.81 | 0.074 | 1.23 | 0.83-1.83 | 0.298 | |
| Depth of tumour invasion (T1-T2 vs. T3-T4) | 1.18 | 0.72-1.93 | 0.512 | 0.81 | 0.42-1.55 | 0.526 | |
| Lymph node metastasis (N0-1 vs. N2-3) | 1.14 | 0.76-1.71 | 0.529 | 0.84 | 0.52-1.37 | 0.495 | |
| pTNM stage (I-II vs. III) | 2.78 | 1.01-7.72 | 0.049* | 4.94 | 1.46-16.69 | 0.010* | |
| Lymphatic vessel invasion (Negative vs. Positive) | 1.34 | 0.71-2.54 | 0.365 | 1.46 | 0.64-3.33 | 0.371 | |
| Venous invasion (Negative vs. Positive) | 0.58 | 0.31-1.07 | 0.081 | 0.54 | 0.25-1.14 | 0.107 | |
| Adjuvant chemotherapy (No vs. Yes) | 0.74 | 0.32-1.70 | 0.484 | 1.29 | 0.47-3.57 | 0.619 | |
| Preoperative CONUT score (Low vs. High) | 2.02 | 1.19-3.43 | 0.010* | 3.45 | 1.68-7.10 | 0.001* | |
| Preoperative CTC status (Negative vs. Positive) | 4.79 | 1.82-12.60 | 0.002* | 4.70 | 1.05-21.03 | 0.043* | |
| Model 2 | |||||||
| Histopathological type (Well-moderate vs. Poor) | 1.27 | 0.93-1.73 | 0.127 | 1.22 | 0.82-1.80 | 0.323 | |
| Depth of tumour invasion (T1-T2 vs. T3-T4) | 1.12 | 0.69-1.82 | 0.647 | 0.80 | 0.42-1.53 | 0.500 | |
| Lymph node metastasis (N0-1 vs. N2-3) | 1.12 | 0.75-1.67 | 0.592 | 0.84 | 0.52-1.37 | 0.491 | |
| pTNM stage (I-II vs. III) | 2.99 | 1.09-8.16 | 0.033* | 5.01 | 1.49-16.82 | 0.009* | |
| Lymphatic vessel invasion (Negative vs. Positive) | 1.28 | 0.68-2.39 | 0.442 | 1.43 | 0.63-3.24 | 0.390 | |
| Venous invasion (Negative vs. Positive) | 0.63 | 0.34-1.16 | 0.138 | 0.55 | 0.26-1.16 | 0.117 | |
| Adjuvant chemotherapy (No vs. Yes) | 0.77 | 0.34-1.73 | 0.526 | 1.31 | 0.48-3.60 | 0.596 | |
| Preoperative CONUT-CTC score (0 vs. 1 vs. 2) | 2.66 | 1.79-3.96 | <0.001* | 3.75 | 2.14-6.57 | <0.001* | |
Notes: *indicates P<0.05. CRC, colorectal cancer; HR, hazard ratio; CI, confidence interval; TNM, tumour-node-metastasis; CEA, carcinoembryonic antigen; CONUT, controlling nutritional status; CTC, circulating tumour cell.