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. 2019 May 24;20(10):2564. doi: 10.3390/ijms20102564

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Altered contrast in the disseminated model imaged with ⁸⁹Zr-DFO-9E7.4 at 24 h post-injection. Bioluminescence imaging (A) revealing lesions in both femurs. Maximum intensity projections of PET and CT imaging with ⁸⁹Zr-DFO-9E7.4 at 24 h post-injection (PI) (B) and maximum intensity projections of PET imaging with ⁸⁹Zr-DFO-9E7.4 at 24 h PI (C) showing uptake in both femurs (Mouse 16). Bioluminescence imaging (D) revealing lesions in the sacrum, left femur and both iliac wings. Maximum intensity projections of PET and CT imaging with ⁸⁹Zr-DFO-9E7.4 at 24 h PI (E) and maximum intensity projections of PET imaging with ⁸⁹Zr-DFO-9E7.4 at 24 h PI (F) showing uptake in the sacrum, left femur and both iliac wings (Mouse 17). Multiple false-positive osseous foci were also observed (indicated by green arrows).