Table 1.
Time constants and percentage areas are shown as obtained from maximum likelihood fitting of probability density functions to full open and closed lifetime distributions of single SR K+‐channels from WT and Tric‐a KO
| WT | Tric‐a KO | ||
|---|---|---|---|
| tau (ms) | Area (%) | tau (ms) | Area (%) |
| Closed state | |||
| 5.2 ± 2.2 | 19.4 ± 3.1 | 1.3 ± 0.1* | 23.2 ± 1.7 |
| 25.6 ± 17.7 | 21.3 ± 2.7 | 10.6 ± 2.5 | 21.2 ± 1.9 |
| 138.6 ± 72.6 | 27.5 ± 4.7 | 65.6 ± 17.6 | 20.3 ± 1.5 |
| 810.2 ± 319.7 | 20.2 ± 3.4 | 766.9 ± 406.9 | 17.8 ± 2.4 |
| 4403.9 ± 1666.1 | 11.6 ± 2.0 | 6601.0 ± 2841.2 | 17.5 ± 2.2 |
| Full open state | |||
| 6.4 ± 2.0 | 54.3 ± 9.2 | 2.4 ± 0.2* | 54.2 ± 3.7 |
| 182.3 ± 48.7 | 45.6 ± 9.2 | 81.7 ± 14.3* | 45.8 ± 3.7 |
Data are presented as the mean ± SEM for n = 12 WT experiments and n = 21 Tric‐a KO experiments. Student's t test was used to assess differences between mean tau values of the two groups (* P < 0.05).