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. 2019 May 14;20(10):2381. doi: 10.3390/ijms20102381

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of EVs derived from naïve or electroporated MSC in AKI mice: Functional and morphological evaluation. (A) Creatinine and (B) blood urea nitrogen (BUN) values in AKI mice injected with vehicle alone (Vehicle) or with 165 × 10⁶ EVs derived from naïve MSCs (EV-CTRL) or from electroporated MSCs (EV-EP) transfected with different miRNA mimics (EV-miR127, EV-miR10a, EV-miR486). EVs were injected at day 3 and mice were sacrificed at day 5 after glycerol administration. Results are expressed as mean ± SD; ANOVA with Dunnett’s multiple comparison test was performed. ** p < 0.01 EV-CTRL and EV-EP vs. Vehicle. Morphometric evaluation of (C) hyaline casts and (D) tubular necrosis in AKI mice treated with vehicle alone (Vehicle) or injected with 165 × 10⁶ EVs derived from naïve MSCs (EV-CTRL) or from electroporated MSCs (EV-EP) transfected with different miRNA mimics (EV-miR127, EV-miR10a, EV-miR486). Results are expressed as mean ± SD; ANOVA with Dunnett’s multiple comparison test was performed. ** p < 0.01 EV-CTRL and EV-EP vs. Vehicle.