Table 1.
List of miRNA families for which targets were significantly modulated by extracellular vesicle (EV) administration in acute kidney injury (AKI) mice.
| FC Non-Targets | FC Targets | p | Rank | |
|---|---|---|---|---|
| miR-10abc/10a-5p | 0.03 | 0.06 | 0.0313 | 1 |
| let-7/98/4458/4500 | 0.03 | 0.06 | 0.0476 | 2 |
| miR-127/127-3p | 0.03 | 0.25 | 0.0431 | 12 |
| miR-30abcdef/30abe-5p/384-5p | 0.03 | 0.07 | 0.0003 | 13 |
| miR-29abcd | 0.03 | 0.07 | 0.0047 | 24 |
| miR-192/215 | 0.03 | 0.14 | 0.0035 | 50 |
| miR-140/140-5p/876-3p/1244 | 0.03 | 0.10 | 0.0177 | 72 |
| miR-377 | 0.03 | 0.08 | 0.0203 | 96 |
| miR-202-3p | 0.03 | 0.08 | 0.0060 | 124 |
miRNAs with targets that showed significant down-regulation in EV treated-vs. untreated-AKI mice were listed and correlated with their enrichment in EVs isolated at 100,000 g (p value < 0.05). Non-targets: Median fold change (FC, logarithmic treated vs. untreated) of the genes that are not miRNA targets. Targets: Median FC of the genes that are miRNA targets. p: p-value generated by Mann–Whitney test, comparing the FC of targets vs. non-target miRNAs. Rank: List of the expressed miRNAs based on their abundance inside EVs.